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Gastric carcinogenesis after long-term observation of clinical course without any treatment in a patient with attenuated familial adenomatous polyposis
  1. A Takeda1,
  2. S Bau2,
  3. E Hirooka3,
  4. K Takahashi3,
  5. Y Ohara3,
  6. H Nakayama3,
  7. N Shinozuka3,
  8. I Koyama3
  1. 1Department of Surgical Oncology, Saitama Medical University, Saitama, Japan
  2. 2Department of Pathology, Saitama Medical University
  3. 3Department of Surgical Oncology, Saitama Medical University
  1. Correspondence to:
 A Takeda
 38 Morohongo, Moroyama-machi, Iruma-gun, Saitama 350-0495, Japan; aktake{at}saitama-med.ac.jp

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We report on a 51-year-old female patient with familial adenomatous polyposis (FAP) that developed into advanced gastric cancer after long-term observation without any treatment (>12 years). We observed gastric carcinogenesis using immunohistochemistry. The patient had a FAP pedigree, and onset of FAP is reported in 11 members of her family. During clinic visits, a total of 12 endoscopies of the large bowel were carried out and tubular adenoma of group 2–3 was seen during all examinations. In a recent detailed examination of the upper gastrointestinal tract, Borr type III gastric cancer was found, with many hepatic metastasis lesions and many polyps in the fundic gland (fig 1A,B).

Figure 1

 (A) Many polyps in the fundic gland region and (B) Borr type III advanced gastric cancer with deep ulcer in the upper gastric body, …

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