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Diagnostic relevance of anti-filamentous actin antibodies in autoimmune hepatitis
  1. C Liaskos1,
  2. D-P Bogdanos2,
  3. E T Davies3,
  4. G N Dalekos4
  1. 1Liver Immunopathology, Institute of Liver Studies, King’s College London School of Medicine at King’s College Hospital, Denmark Hill, London, UK
  2. 2Liver Immunopathology, Institute of Liver Studies, King’s College London School of Medicine at King’s College Hospital, Denmark Hill, London, UK
  3. 3Department of Immunology, King’s College Hospital, Denmark Hill, London, UK
  4. 4Academic Liver Unit and Research Laboratory of Internal Medicine, Department of Internal Medicine, Larissa Medical School, University of Thessaly, Larissa, Greece
  1. Correspondence to:
    Dr D-P Bogdanos
    Liver Immunopathology, Institute of Liver Studies, King’s College London School of Medicine at King’s College Hospital, Denmark Hill, London SE5 9RS, UK;dimitrios.bogdanos{at}kcl.ac.uk

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We read with interest the paper by Granito et al1 reporting on the clinical and diagnostic significance of anti-filamentous actin antibodies (A-FAA) in autoimmune hepatitis type 1 (AIH-1). The authors found that A-FAA, measured by a new commercially available ELISA based on a modified cut-off of 30 instead of the manufacturer’s 20 arbitary units (AU), strictly correlates with the smooth muscle antibody glomerular/tubular (SMA-G/T) pattern,2 also known as the microfilament pattern, mostly seen in patients with AIH-1.1 Their findings further indicate F-actin as the predominant, if not the sole, target of AIH-1-specific SMA reactivity, a notion that has been questioned in the past because of the inconsistent results obtained by several actin-based assays.3,4

We agree with Granito et al1

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