We report a case of a 9-cm mixed epithelial and stromal tumour of the kidney in an obese 70-year-old woman with diabetes. The ovarian-type stroma had a spindle cell component that was positive for progesterone receptors and had the hitherto unreported presence of abundant foci of luteinised stromal cells with characteristic immunohistochemical positivity to α-inhibin, calretinin, aromatase and gonadotropin-releasing hormone (GnRH) receptors. We conclude that the stromal component is identical to ovarian cortical stroma.
We believe that ovarian-type stroma occurs in extragenital tumours as a result of an epithelial–stromal interaction in an environment of hormonal hyperstimulation.
- GnRH, gonadotropin-releasing hormone
- MEST, mixed epithelial and stromal tumour
- OTS, ovarian-type stroma
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Competing interests: None declared.
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