We report a case of a 9-cm mixed epithelial and stromal tumour of the kidney in an obese 70-year-old woman with diabetes. The ovarian-type stroma had a spindle cell component that was positive for progesterone receptors and had the hitherto unreported presence of abundant foci of luteinised stromal cells with characteristic immunohistochemical positivity to α-inhibin, calretinin, aromatase and gonadotropin-releasing hormone (GnRH) receptors. We conclude that the stromal component is identical to ovarian cortical stroma.
We believe that ovarian-type stroma occurs in extragenital tumours as a result of an epithelial–stromal interaction in an environment of hormonal hyperstimulation.
- GnRH, gonadotropin-releasing hormone
- MEST, mixed epithelial and stromal tumour
- OTS, ovarian-type stroma
Statistics from Altmetric.com
Competing interests: None declared.
Informed consent has been received for publication of this information
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.