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Hamazaki-Wesenberg bodies in two patients with no history of sarcoidosis
  1. Ryan Winters1,
  2. Masatoshi Kida2,
  3. Kumarasen Cooper2
  1. 1University of Vermont College of Medicine, Burlington, Vermont, USA
  2. 2Department of Pathology, University of Vermont College of Medicine and Fletcher Allen Health Care, Burlington, Vermont, USA
  1. Ryan Winters, Given Box 436, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA; Ryan.Winters{at}uvm.edu

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Patient A

A 76-year-old woman underwent a left nephrectomy for a retroperitoneal angiomyolipoma, which was contacting and displacing the spleen and left kidney. Intraoperative frozen sections of a periportal lymph node revealed brown pigment within the sinuses. Permanent sections of this specimen demonstrated a reactive lymph node with lipogranuloma formation, prominent histiocytes, and ovoid, dark-brown to yellow structures located within the sinuses, associated with the prominent histiocytes. These structures ranged from 0.25–1.0 times the size of a lymphocyte nucleus and were primarily extracellular, with only occasional examples noted within histiocytes.

Patient B

A 55-year-old man underwent a right hemicolectomy for a tubulovillous adenoma of the ascending colon. Preoperative CT scan revealed mildly enlarged retroperitoneal lymphadenopathy, but no other evidence of metastasis. Eleven lymph nodes were located within the pericolic adipose tissue of the specimen, all negative for malignancy. Three of the eleven nodes demonstrated ovoid, dark-brown structures within the subcapsular sinuses, as …

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