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Angiosarcoma of bone marrow with unusual expression of chymase: diagnosis in a trephine biopsy specimen
  1. F Noack1,
  2. L Balleisen2,
  3. P Valent3,
  4. H-P Horny4
  1. 1Department of Pathology, University of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany
  2. 2Department of Haematology and Oncology, Evangelisches Krankenhaus, Hamm, Germany
  3. 3Department of Internal Medicine I, Division of Haematology and Haemostaseology, University of Vienna, Austria
  4. 4Department of Pathology, University of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany

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Angiosarcoma is a very rare vascular neoplasm, comprising less than 1% of all sarcomas. Involvement of the bone marrow is distinctly uncommon and almost invariably seen in patients with disseminated disease. Primary angiosarcoma of the bone/bone marrow, however, is extremely rare and, to the best of the authors knowledge, has not been reported to be diagnosed in a trephine biopsy.1

A 77-year-old woman presented with acute back pain. A mastectomy had been performed for carcinoma of the left breast 16 years previously. Her past medical history was otherwise unremarkable. On physical examination, the patient showed hemisensory loss of the left leg. MRI and radionuclide bone scan revealed a large tumour mass …

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