Article Text

PDF
Non-operative breast pathology: lobular neoplasia
  1. Jorge S Reis-Filho1,
  2. Sarah E Pinder2
  1. 1
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
  2. 2
    Department of Histopathology, Addenbrooke’s Hospital, Cambridge, UK
  1. Dr Jorge S Reis-Filho, The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK; Jorge.Reis-Filho{at}icr.ac.uk

Abstract

Lobular neoplasia is a relatively uncommon lesion, which is frequently diagnosed in biopsy specimens taken for other reasons. Although the histological features of this lesion are well known, its biological significance as a “risk indicator” or “breast cancer precursor” has been a matter of debate. This review provides an update on recent clinicopathological and molecular data on lobular neoplasia and how these have changed the way these lesions are perceived and, most importantly, managed. Furthermore, the current recommendations for the management of lobular neoplasia diagnosed on core needle biopsies proposed in the National Health Service Breast Cancer Screening guidelines are discussed.

  • lobular carcinoma in situ
  • atypical lobular hyperplasia
  • E-cadherin
  • pleomorphic lobular carcinoma
  • β-catenin

Statistics from Altmetric.com

Footnotes

  • Competing interests: None declared.

  • Abbreviations:
    ADH
    atypical ductal hyperplasia
    ALH
    atypical lobular hyperplasia
    CGH
    comparative genomic hybridisation
    CNB
    core needle biopsy
    DCIS
    ductal carcinoma in situ
    ILC
    invasive lobular cancer
    LCIS
    lobular carcinoma in situ
    LN
    lobular neoplasia

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.