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Expression of the polycomb-group gene BMI1 is related to an unfavourable prognosis in primary nodal DLBCL
  1. Joost C van Galen1,*,
  2. Jettie J F Muris1,*,
  3. Joost J Oudejans1,
  4. Wim Vos1,
  5. Cindy P E Giroth1,
  6. Gert J Ossenkoppele2,
  7. Arie P Otte3,
  8. Frank M Raaphorst1,4,
  9. Chris J L M Meijer1
  1. 1Departments of Pathology, VU Medical Center, Amsterdam, The Netherlands
  2. 2Departments of Haematology, VU Medical Center, Amsterdam, The Netherlands
  3. 3Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
  4. 4Crucell Holland BV,Leiden, The Netherlands
  1. Correspondence to:
 Dr J J Oudejans
 Department of Clinical Pathology, VU Medical Center, De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands; jj.oudejans{at}vumc.nl

Abstract

Background: : Clinical outcome in patients with diffuse large B cell lymphomas (DLBCL) is highly variable and poorly predictable. Microarray studies showed that patients with DLBCL with a germinal centre B cell-like (GCB) phenotype have a better prognosis than those with an activated B cell-like (ABC) phenotype. The BMI1 proto-oncogene was identified as one of the genes present in the signature of the ABC type of DLBCL, associated with a poor prognosis.

Objectives: : (1) To investigate, in primary nodal DLBCL, the expression of BMI1 and its association with clinical outcome and DLBCL signature; (2) to look for an association between BMI1 expression and the expression of its putative downstream targets p14ARF and p16INK4a.

Results: : BMI1 expression was found to be associated with poor clinical outcome, but not clearly with an ABC-like phenotype of DLBCL. Expression of BMI1 was frequently, but not always, related to low levels of expression of p14ARF and p16INK4a.

Conclusion: : Expression of BMI1 is associated with an unfavourable clinical outcome of primary nodal DLBCL.

  • ABC, activated B cell
  • DLBCL, diffuse large B cell lymphomas
  • GCB, germinal centre B cells

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Footnotes

  • * These authors contributed equally to this study

  • Published Online First 12 July 2006

  • Competing interests: None.

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