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Three cases of pancreatic serous cystadenoma and endocrine tumour
  1. Stella Blandamura1,
  2. Anna Parenti1,
  3. Barbara Famengo1,
  4. Alessandra Canesso1,
  5. Paolo Moschino3,
  6. Claudio Pasquali2,
  7. Sara Pizzi1,
  8. Vincenza Guzzardo1,
  9. Vito Ninfo1
  1. 1Department of Oncological and Surgical Sciences, Section of Pathological Anatomy, University of Padova, Padova, Italy
  2. 2Department of Medical and Surgical Sciences, Section of Surgical Clinic IV, University of Padova, Padova, Italy
  3. 3Section of General Surgery, Azienda Ospedaliera, Padova, Italy
  1. Correspondence to:
 Dr S Blandamura
 Department of Oncological and Surgical Sciences, Section of Pathological Anatomy, University of Padova, Via Gabelli 61, 35121 Padova, Italy; stella.blandamura{at}unipd.it

Abstract

Aims: To report three cases of serous cystadenoma and endocrine tumour in the same pancreas, to review the literature and to evaluate the clinicopathological features of the tumours.

Cases: Three women (71, 57 and 31 years old) were admitted to hospital, two for diseases unrelated to the pancreas and the third for increasing obstructive jaundice in von Hippel-Lindau disease. Preoperative examination showed two distinct lesions in the first patient and only cystic lesions in the other two.

Results: Histological examination of the pancreas showed one serous oligocystic adenoma associated with a benign, well-differentiated endocrine tumour, one serous oligocystic adenoma associated with an endocrine microadenoma, and a von Hippel-Lindau-related cystic neoplasm with a well-differentiated endocrine carcinoma.

Conclusions: Serous cystadenoma associated with endocrine tumour shows some clinicopathological differences with respect to the two tumours considered separately, and with respect to von Hippel-Lindau-related cases, although there is no convincing evidence at present to justify considering this association as a separate entity.

  • MEN, multiple endocrine neoplasia
  • MUC, mucin
  • NSE, neurone-specific enolase
  • PAS, periodic acid Schiff
  • SCN, serous cystic neoplasm
  • SMA, serous microcystic adenoma
  • SOIA, serous oligocystic ill-defined adenoma
  • VHL, von Hippel-Lindau disease
  • VHL-CN, von Hippel-Lindau-associated cystic neoplasm

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Footnotes

  • Published Online First 27 April 2006

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