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Cervical embryonal rhabdomyosarcoma and ovarian Sertoli–Leydig cell tumour: a more than coincidental association of two rare neoplasms?
  1. Gareth E McClean1,
  2. Susy Kurian2,
  3. Noel Walter2,
  4. A Kekre3,
  5. W Glenn McCluggage1
  1. 1Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
  2. 2Department of Pathology, Christian Medical College, Vellore, South India
  3. 3Department of Gynaecology, Christian Medical College, Vellore, South India
  1. Correspondence to:
 Professor W G McCluggage
 Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast BT12 6BL, Northern Ireland; glenn.mccluggage{at}bll.n-i.nhs.uk

Abstract

A case in which an embryonal rhabdomyosarcoma of the cervix and an ovarian Sertoli–Leydig cell tumour of intermediate differentiation occurred in a 13-year-old girl is described. Although initially considered as a chance association, a review of the literature showed the co-occurrence of these two uncommon neoplasms in three previous cases. The reason for this association, which is thought to be more than coincidental, is not known, although an underlying genetic abnormality is a possibility. The ovarian tumour in this case was characterised by the presence of foci of cells with extremely pleomorphic nuclei, which initially raised the possibility of metastatic rhabdomyosarcoma. These were interpreted as foci of bizarre nuclei within the Sertoli–Leydig cell tumour.

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Footnotes

  • Competing interests: None declared.

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