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  • Pulmonary mucosa-associated lymphoid tissue lymphoma with strong nuclear B-cell CLL/lymphoma 10 (BCL10) expression and novel translocation t(1;2)(p22;p12)/immunoglobulin κ chain-BCL10

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Case report
Pulmonary mucosa-associated lymphoid tissue lymphoma with strong nuclear B-cell CLL/lymphoma 10 (BCL10) expression and novel translocation t(1;2)(p22;p12)/immunoglobulin κ chain-BCL10
  1. Shih-Sung Chuang1,
  2. Hongxiang Liu2,
  3. Hongtao Ye2,
  4. Jose I Martín-Subero3,
  5. Reiner Siebert3,
  6. Wen-Tsung Huang4
  1. 1Department of Pathology, Chi-Mei Medical Center, Tainan, Taiwan; Taipei Medical University, Taipei City, Taiwan
  2. 2Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, UK
  3. 3Institute of Human Genetics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany
  4. 4Division of Hemato-oncology, Department of Internal Medicine, Chi-Mei Hospital, Liouying, Tainan, Taiwan
  1. Correspondence to:
 Dr H Ye
 Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Box 231, Level 3,Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UK; hty21{at}cam.ac.uk

https://doi.org/10.1136/jcp.2006.041012

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    Mucosa-associated lymphoid tissue (MALT) lymphoma is associated with recurrent chromosomal translocations t(11;18)(q21;q21), t(14;18)(q32;q21), t(1;14)(p22;q32) and t(3;14)(p14.1;q32).1,2 While t(11;18)(q21;q21) fuses the N-terminus of the API2 (11q21) gene to the C-terminus of the MALT1 (18q21) gene and generates a functional API2–MALT1 product, t(1;14)(p22;q32), t(14;18)(q32;q21) and t(3;14)(p14.1;q32) bring the BCL10(1p22), MALT1 (18q21) and FOXP1(3p14) genes, respectively, under the control of the immunoglobulin heavy chain (IGH, 14q32) enhancer, leading to their overexpression.1 Interestingly, the oncogenic activity of the first three chromosomal translocations is linked by the physiological role of BCL10 and MALT1 in antigen receptor-mediated nuclear factor kappa B (NFκB) activation.1

    Primary pulmonary MALT lymphomas show heterogeneous cytogenetic abnormalities, including aneuploidy and translocations. Among the translocations described in MALT lymphoma of this site, t(11;18)(q21;q21) is the most common, occurring in up to 50% of cases, and t(14;18)(q32;q21) and t(1;14)(p22;q32) are relatively rare.3–5 The overall incidence of t(1;14)(p22;q32) is approximately 3% in MALT lymphomas of different sites, and can be up to 10% in pulmonary cases.4–6 Recently, Achuthan et al7 reported t(1;2)(p22;p12) involving the BCL10 and the immunoglobulin kappa (IGK) light chain genes as a novel translocation in a gastric MALT lymphoma. Here we report the first case of pulmonary MALT lymphoma with this translocation, indicating that the t(1;2)(p22;p12) is a recurrent cytogenetic event in MALT lymphoma.

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    Footnotes

    • Published Online First 10 November 2006

    • Competing interests: None declared.

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    • Corrections
      CORRECTION
      BMJ Publishing Group Ltd and Association of Clinical Pathologists
      Journal of Clinical Pathology 2007; 60 959-959 Published Online First: 27 Jul 2007. doi: 10.1136/jcp.2006.041012corr1