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Histopathological risk factors for lymph node metastasis in submucosal invasive colorectal carcinoma of pedunculated or semipedunculated type
  1. Dae Kyung Sohn,
  2. Hee Jin Chang,
  3. Ji Won Park,
  4. Dong Hyun Choi,
  5. Kyung Su Han,
  6. Chang Won Hong,
  7. Kyung Hae Jung,
  8. Dae Yong Kim,
  9. Seok-Byung Lim,
  10. Hyo Seong Choi,
  11. Seung-Yong Jeong
  1. Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea
  1. Correspondence to:
 Dr Hee Jin Chang
 Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, 809 Madu-dong, Ilsan-gu, Goyang, Gyeonggi 411-769, Korea; heejincmd{at}yahoo.com

Abstract

Aims: To evaluate the histopathological risk factors for lymph node metastasis in cases of pedunculated or semipedunculated submucosal invasive colorectal carcinoma (SICC).

Methods: A total of 48 patients with non-sessile SICC who underwent systematic lymph node dissection were included. Tumour size, histological grade, angiolymphatic invasion, tumour budding, dedifferentiation, objective submucosal invasion depth from the identified muscularis mucosa, relative invasion depth of the submucosal layer, and depth of stalk invasion were investigated histopathologically.

Results: Lymph node metastasis was observed in seven cases (14.6%). Univariate analysis showed angiolymphatic invasion and tumour budding to be significantly associated with lymph node metastasis. Multivariate analysis showed that tumour budding was the only independent factor associated with lymph node metastasis in cases of non-sessile SICC.

Conclusions: Results indicate that tumour budding is a useful risk factor for predicting lymph node metastasis in cases of pedunculated or semipedunculated SICC.

  • SICC, submucosal invasive colorectal carcinoma
  • colorectal carcinoma
  • pedunculated
  • lymph node metastasis
  • risk factors
  • tumour budding

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Footnotes

  • Published Online First 22 September 2006

  • Funding: This work was supported by a research grant from the National Cancer Center, Korea.

  • Competing interests: None declared.

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