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In chronic follicular gastritis the lymphoid follicles are usually localised in the lamina propria.1 In lymphoid hyperplasia associated with a chronic peptic ulcer, numerous lymphoid follicles are sometimes present in the ulcer base, in which the muscularis propria has usually been destroyed and replaced by scar tissue.2 The histology of Helicobacter-associated chronic gastritis with numerous reactive lymphoid follicles and an indistinct poorly developed marginal zone may closely simulate lymphoma and pose a diagnostic challenge. We present an extreme example of florid follicular gastritis, which mimicked a malignant neoplasm clinically and pathologically. To our knowledge, such florid hyperplasia with reactive lymphoid follicles extending into the muscularis propria and beyond has never been reported.
A 65-year-old man presented with intermittent abdominal hunger pain for one month. Endoscopic biopsies revealed …