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Oestrogen receptor β immunohistochemistry: time to get it right?
  1. V Speirs1,
  2. C A Green1,
  3. A M Shaaban2
  1. 1Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK
  2. 2St James’s Institute of Oncology, St James’s University Hospital, Leeds, UK
  1. Dr V Speirs, Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, St James’s University Hospital, Leeds LS9 7TF, UK; v.speirs{at}leeds.ac.uk

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We read with interest the paper by Borgquist et al, published recently in this journal.1 In their article, the authors aimed to investigate the impact of oestrogen receptor β (ERβ) expression on breast cancer outcome using a cohort of 512 tumours represented in tissue microarray (TMA). Since the discovery of ERβ over a decade ago, this has been the goal of many research groups. However, progress in this area has been impeded by the lack of a consensus in terms of choice of primary antibody and cut-off value used to determine ERβ positivity.2 3 Additionally, we know that ERβ exists as five isoforms (ERβ1–5), each formed by alternative splicing of the last coding exon,4 5 which …

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  • Letters
    S Borgquist C Holm M Stendahl L Anagnostaki G Landberg K Jirström