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False-negative assessment of oestrogen receptor on needle core biopsy of invasive carcinoma of the breast
  1. A H S Lee,
  2. Z Hodi,
  3. I O Ellis
  1. Department of Histopathology, Nottingham University Hospitals, Nottingham, UK
  1. Dr Andrew H S Lee, Department of Histopathology, Nottingham University Hospitals, City Hospital Campus, Nottingham NG5 1PB, UK; andrew.lee{at}nuh.nhs.uk

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In a recent study we compared oestrogen receptor (ER) status in invasive mammary carcinomas assessed on core biopsy and surgical specimens with immunohistochemistry using a cut-off of H score of 10.1 The agreement was 98.8% in patients with less than 60 days between the two procedures, and 93% for patients with more than 60 days between the procedures. A potential concern is false-negative assessment on core biopsy (ER negative on core biopsy and ER positive on the surgical specimen). This occurred in 2 of …

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