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Snippets in surgical pathology
  1. Kumarasen Cooper,
  2. Runjan Chetty
  1. kum.cooper@vtmednet.org
  2. runjan.chetty@uhn.on.ca

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This section features synopses of pertinent practical publications that appear in Pathology journals in the respective sub-specialties. The summaries are mere guidelines and personal opinions of the two authors. The articles selected are diverse but occasionally reflect the authors’ bias and are from the more widely read pathology journals. It is not intended to be an assiduous search of every publication in every Pathology journal, but more of a general indication of some of the monthly highlights through the eyes of the authors.

Hopefully, these snippets will provide the reader with enough to glean some facts and tips, as well as encourage them to read the entire article if necessary.

Journal of Clinical Pathology, September 2008

O’Donnell S, Swan N, Crotty P, et al. Assessment of the clinical significance of intestinal spirochaetosis. J Clin Pathol 2008;61:1029–33.

Eighteen cases (none were immunocompromised) encountered over an 8-year period were reviewed; 50% of patients presented with diarrhoea and 16.7% had rectal bleeding. There is no correlation between symptoms and persistence/eradication. Hence the recommendation is to adopt a “wait and see” approach towards treatment, with a trial of treatment if symptoms are severe/persistent.

Aulmann S, Schleibaum J, Penzel R, et al. Gains of chromosome region 3q26 in intraepithelial neoplasia and invasive squamous cell carcinoma of the vulva are frequent and independent of HPV status. J Clin Pathol 2008;61:1034–7.

Two forms of vulval intraepithelial neoplasia (VIN) occur: the usual type or Bowenoid HPV-driven variety and the differentiated (simplex) type that is associated with chronic inflammation. 3q26 gains were analysed in both types by FISH. Gains were present in all cases of differentiated type VIN and 50% of usual type VIN. Eighty-one per cent of squamous cancers showed 3q26 gains irrespective of type and HPV status. Detection of 3q26 gain by FISH may be of use …

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