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Short- and long-term effects of a training session on pathologists’ performance: the INQAT experience for histological grading in breast cancer
  1. A Paradiso1,
  2. I O Ellis2,
  3. F A Zito3,
  4. E Marubini4,
  5. S Pizzamiglio5,
  6. P Verderio5
  1. 1Italian Network for Quality Assessment of Tumour Biomarkers—Project Coordinator, National Cancer Institute, Bari, Italy
  2. 2Department of Histopathology, Nottingham City Hospital, Nottingham, UK
  3. 3Italian Network for Quality Assessment of Tumour Biomarkers—Reference Unit, National Cancer Institute, Bari, Italy
  4. 4Italian Network for Quality Assessment of Tumour Biomarkers—Biostatistics Unit, Università degli Studi di Milano, Milan, Italy
  5. 5Italian Network for Quality Assessment of Tumour Biomarkers—Biostatistics Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
  1. Dr P Verderio, Unità Operativa di Statistica Medica e Biometria, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian, 1, 20133 Milan, Italy; paolo.verderio{at}istitutotumori.mi.it

Abstract

Although the introduction of the Nottingham/Tenovus classification has improved the criteria to assess the histological grading in breast cancer, several quality control studies have shown that good results in terms of reproducibility are hard to obtain. This paper reports the results obtained during an implemented quality control programme for histological grading aimed at evaluating the short- and long-term effects of a training session on pathologists’ performance. The interobserver reproducibility for grading score along with its components was assessed. The reproducibility between each pathologist and the reference values was also evaluated, as well as the contribution of each grading category to the observed reproducibility. Results show the weakness of a single training course in improving the long-term performance of the participating pathologists, suggesting the need to continuously monitor the quality of the grading determination by planning quality control studies and training sessions sequentially repeated in short time intervals.

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Footnotes

  • Funding: Supported by PS Oncologia #CU03.00386 CNR-MIUR-2003 and PF Ministry of Health, Italian Government.

  • Competing interests: None declared.

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