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This section will feature features synopses of pertinent practical publications that appear in Pathology journals in the respective sub-specialties. The summaries are mere guidelines and personal opinions of the two authors. The articles selected are diverse but occasionally reflect the authors’ bias and are from the more widely read pathology journals. It is not intended to be an assiduous search of every publication in every Pathology journal, but more of a general indication of some of the monthly highlights through the eyes of the authors.
Hopefully, these snippets will provide the reader with enough to glean some facts and tips, as well as encourage them to read the entire article if necessary.
BRITISH JOURNAL OF HAEMATOLOGY, SEPTEMBER 2008
Biss TT, Brandao LR, Kahr WH, et al. Clinical features and outcome of pulmonary embolism in children. Br J Haematol 2008;142:808–18.
Pulmonary embolism may be an unconsidered and under-recognised illness in childhood. This research paper thoroughly and interestingly details the presentation, diagnosis, management and outcomes of 56 children who presented with pulmonary embolism to a single centre. The author successfully raises awareness of the condition in the mind of the reader, of the deficiencies in the evidence base for its optimal management, and of the differences in risk factors and outcomes between adults and children.
Jansen NW, Roosendaal G, Hooiveld MJ, et al. Interleukin-10 protects against blood-induced joint damage. Br J Haematol 2008;142:953–61.
Arthropathy due to recurrent haemarthrosis is debilitating, deforming and difficult to manage. Joint bleeding produces arthropathy by inflammatory and degenerative mechanisms. Interleukin-10 has beneficial effects on cartilage in vitro and reduces inflammation. By demonstrating in vitro that interleukin-10 improves outcome in cartilage cultured with blood, the authors offer the hope of additional prophylactic therapies. The paper concludes by calling for clinical trials.
Scully M, Yarranton H, Liesner R, Cavenagh …