|Hepatocellular injury||Isolated increase in ALT >twice normal, or ALT/ALP ⩾5|
|Cholestatic injury||Isolated increase in ALP >twice normal, or ALT/ALP ⩽2|
|Mixed injury||ALT and ALP are increased, and 2<ALT/ALP<5|
|Acute injury||Above changes present for <3 months|
|Chronic injury||Above changes present for >3 months|
|Chronic liver disease||This term is used only after histological confirmation|
ALP, alkaline phosphatase; ALT, alanine aminotransferase; CIOMS, Council for International Organizations of Medical Sciences.