J Clin Pathol 62:481-492 doi:10.1136/jcp.2008.058248
  • Review

Histological patterns in drug-induced liver disease

Table 1 CIOMS consensus criteria for terminology in drug-induced liver injury
Terminology Criteria
Hepatocellular injury Isolated increase in ALT >twice normal, or ALT/ALP ⩾5
Cholestatic injury Isolated increase in ALP >twice normal, or ALT/ALP ⩽2
Mixed injury ALT and ALP are increased, and 2<ALT/ALP<5
Acute injury Above changes present for <3 months
Chronic injury Above changes present for >3 months
Chronic liver disease This term is used only after histological confirmation
  • ALP, alkaline phosphatase; ALT, alanine aminotransferase; CIOMS, Council for International Organizations of Medical Sciences.

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