Statistics from Altmetric.com
It has been our practice to perform immunoglobulin (Ig)A anti-tissue transglutaminase (tTG), IgA/IgG antiendomysial (EMA) and IgA/IgG antigliadin (AGA) antibody tests for children under 3 years of age being investigated for coeliac disease. This was based on data showing that EMA may be negative in children. In a study of 277 children under 2 years of age who had biopsy-proven untreated coeliac disease, 88% were EMA positive, 100% were IgG-AGA positive, and 84% were IgA-AGA positive. Eleven per cent of patients were positive for AGA only (though 25% of these were positive for IgG-AGA only).1 The overall AGA specificity is poor, especially that of IgG-AGA.2 Importantly, over a third of AGA-positive young children became spontaneously negative over the following 3 years.3
Data on using AGA alongside recombinant human tTG-based tests are limited and study sizes are small. Equivalent sensitivity of tTG and EMA has been shown with AGA in …
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.