Article Text

PDF
CD30-positive diffuse large B-cell lymphoma with microvillous features: so-called microvillous lymphoma
  1. A Liu1,
  2. Y Sugisaki2,
  3. M Hosone2,
  4. S Namimatsu2,
  5. S Maeda2,
  6. Z Naito2,
  7. M Ghazizadeh1
  1. 1
    Central Institute for Electron Microscopic Researches, Nippon Medical School, Tokyo, Japan
  2. 2
    Department of Pathology, Nippon Medical School, Tokyo, Japan
  1. Correspondence to Dr A Liu, Central Institute for Electron Microscopic Researches, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-8602 Japan; aimin{at}nms.ac.jp

Abstract

A case of CD30-positive microvillous lymphoma (MVL) in an 87-year-old man who was encountered generalised lymphadenopathy is presented. Histopathologically, the tumour showed a morphological mimic of anaplastic large cell lymphoma (ALCL) with sinusoidal growth pattern. Immunohistochemically (IHC), the tumour cells were CD30+, CD20+, CD45+, BCL-2+, BCL-6+, MUM1+, Ki-67+, CD45RO, CD3, CD10, CD15, CD56, EMA, TIA-1 and ALK. Flow cytometry confirmed the IHC. In situ hybridisation for Epstein–Barr virus RNA was negative. Electron microscopically, the tumour cells were similar to large transformed lymphocytes and had circumferentially profuse microvillous projections resembling those of epithelial mesothelioma cells. In conclusion, CD30-positive MVLs are indistinguishable from ALCLs that have ultrastructural microvillous projections by morphology alone. However, the lack of EMA, TIA-1 and ALK expression in this MVL case facilitated a definite distinction from ALCLs. The results of a panel of three markers (CD10, Bcl-6+ and MUM1+) suggested that the present case of CD30-positive MVLs has an activated non-germinal centre B-cell origin.

Statistics from Altmetric.com

Footnotes

  • Competing interests None.

  • Ethics approval Ethics approval was obtained.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.