Article Text

PDF
Constructing prognostic model incorporating the 2004 WHO/ISUP classification for patients with non-muscle-invasive urothelial tumours of the urinary bladder
  1. Chin-Chen Pan1,
  2. Yen-Hwa Chang2,
  3. Kuang-Kuo Chen2,
  4. Hui-Jung Yu1,
  5. Chih-Hao Sun1,
  6. Donald M T Ho1
  1. 1Department of Pathology, Taipei Veterans General Hospital & National Yang-Ming University, Taipei, Taiwan
  2. 2Division of Urology, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan
  1. Correspondence to Dr Chin-Chen Pan, Department of Pathology, Taipei Veterans General Hospital, No 201, Shi-Pai Rd, Sec 2, Taipei 11217, Taiwan; ccpan{at}vghtpe.gov.tw

Abstract

Aim To construct a prognostic model for recurrence-free survival (RFS), progression-free survival (PFS) and cancer-specific survival (CSS) for patients who have undergone transurethral resection of non-muscle-invasive (pTa/pT1) urinary bladder urothelial tumours.

Methods 1366 patients who had undergone transurethral resection of primary non-muscle-invasive urothelial tumours (pTa, 891 patients; pT1, 475 patients) confined to the bladder were retrospectively studied. Tumours were classified according to the 2004 WHO/International Society of Urologic Pathology grading system. Kaplan–Meier and stepwise Cox regression models were applied, and 200 bootstrap resamples were used to generate survival estimates and 95% CIs. A nomogram was developed that incorporated significant variables predicting survival.

Results RFS, PFS and CSS probabilities for non-muscle-invasive bladder urothelial tumours were calculated. Incorporating salient prognostic factors (tumour grade, pT stage, patient age, status of intravesical instillation), the model satisfactorily predicted PFS (concordance index=0.79) and CSS (concordance index=0.87).

Conclusions Robust nomograms were created to predict PFS and CSS. These data provide an overall perspective of disease outcomes which may aid in developing individualised follow-up programmes.

  • Non-muscle-invasive urothelial tumour
  • urinary bladder
  • prognostic model
  • nomogram
  • recurrence
  • progression
  • survival
  • urinary tract tumours

Statistics from Altmetric.com

Footnotes

  • Funding The work was supported by a grant from Taipei Veterans General Hospital (No V97C1-009).

  • Competing interests None.

  • Ethics approval This study was conducted with the approval of the institutional review board of Taipei Veterans General Hospital (No 96-06-10A).

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.