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Haemoglobin Bonn in a Chinese family as a cause of spurious hypoxaemia measured by pulse oximetry
  1. Chi-Chiu So1,
  2. Amy Y Chan1,
  3. Eudora Y Chow2,
  4. Shek-Ying Lin3,
  5. Sze-Fai Yip4,
  6. Siu-Cheung Szeto5,
  7. Li-Chong Chan1
  1. 1Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
  2. 2Department of Pathology, United Christian Hospital, Hong Kong SAR, China
  3. 3Department of Medicine, United Christian Hospital, Hong Kong SAR, China
  4. 4Department of Medicine, Tuen Mun Hospital, Hong Kong SAR, China
  5. 5Department of Pathology, Tuen Mun Hospital, Hong Kong SAR, China
  1. Correspondence to Dr Chi-Chiu So, Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China; scc{at}pathology.hku.hk

Abstract

Haemoglobin (Hb) Bonn is a newly described benign Hb variant that causes falsely depressed oxygen saturation as measured by pulse oximetry. It was found to be associated with mild haemolysis. Since its first report in a German family, no further cases have been documented in the literature. We report the first Chinese family with this Hb variant and confirm its unusual clinical presentation. No evidence of haemolysis was seen. The absence of consistent abnormalities in routine Hb tests such as high-performance liquid chromatography and gel electrophoresis means that spurious hypoxaemia is the only clue to its presence, and genotypic analysis is the preferred method for definitive diagnosis. Its positive identification is important for counselling and will help to avoid unnecessary investigation and treatment for this benign condition.

  • Hb Bonn
  • Chinese
  • phenotype
  • oxygen saturation
  • spurious hypoxaemia
  • haemoglobinopathy

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Footnotes

  • Competing interests None.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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