Article Text

PDF
Endometrial carcinoma: controversies in histopathological assessment of grade and tumour cell type
  1. Blaise A Clarke1,
  2. C Blake Gilks2
  1. 1Department of Pathology and Laboratory Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada
  2. 2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver General Hospital, Vancouver, British Columbia, Canada
  1. Correspondence to C Blake Gilks, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver General Hospital, 920 W 10th Ave, Vancouver, Canada BC V5Z 1M9; blake.gilks{at}vch.ca

Abstract

Histopathological assessment of tumour grade and cell type is central to the management of endometrial carcinoma, guiding the extent of surgery and the use of adjuvant radiation therapy and chemotherapy. Endometrioid carcinomas are usually low grade but high-grade examples are encountered, and they have a significantly worse prognosis, similar to that of high-grade subtypes such as serous and clear cell carcinoma. This article reviews the various grading systems that have been proposed for use with endometrioid endometrial carcinoma, and discusses the recent progress in cell type assignment, including the use of immunohistochemistry as a diagnostic adjunct.

  • Cancer
  • carcinoma
  • endometrial
  • endometrium
  • grade
  • subtype
  • uterine

Statistics from Altmetric.com

Footnotes

  • Competing interests None.

  • Provenance and peer review Commissioned; not externally peer reviewed.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.