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This section features synopses of pertinent practical publications that appear in Pathology journals in the respective sub-specialties. The summaries are mere guidelines and personal opinions of the two authors. The articles selected are diverse but occasionally reflect the authors' bias and are from the more widely read pathology journals. It is not intended to be an assiduous search of every publication in every Pathology journal, but more of a general indication of some of the monthly highlights through the eyes of the authors.
Hopefully, these snippets will provide the reader with enough to glean some facts and tips, as well as encourage them to read the entire article if necessary.
American Journal of Clinical Pathology
Trpkov K, Bartczak-McKay J, Yilmaz A. Usefulness of cytokeratin 5/6 and AMACR applied as double sequential immunostains for diagnostic assessment of problematic prostate specimens. Am J Clin Pathol 2009;132:211–20.
A double sequential immunostain (CK5/6 and AMACR) for problem prostate biopsies was used in 110 consecutive cases. Correlation with morphology was done, and all cancers were CK5/6 negative (100% specificity). AMACR showed diffuse or focal positivity in 96.8% of cancers and 85% of high-grade PIN lesions, and 80% positivity in atypical cases. The authors suggest this double staining as an alternative to the cocktails that are routinely used.
Antinori S, Nebuloni M, Magni C, et al. Trends in the postmortem diagnosis of opportunistic invasive fungal infections in patients with AIDS. Am J Clin Pathol 2009;132:221–7.
The importance/role of the autopsy is once again demonstrated in this study showing the varying prevalences/trends of opportunistic invasive fungal infections in AIDS patients. During the period 1984–2002, a decrease in Pneumocystis/Cryptococcus and an increase in Candida/Zygomycosis prevalence rates were noted, while aspergillus/histoplasmosis infections remained stable.
Ross JS, Slodkowska EA. Circulating and disseminated tumor cells in the management …