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Correspondence
An unusual breast malignant peripheral nerve sheath tumour and review of the literature
  1. Liu Fangfang1,
  2. Shen Danhua1,
  3. Liao Songlin2,
  4. Zhong Yanfeng2
  1. 1Department of Pathology, Peking University People's Hospital, Beijing, China
  2. 2Department of Pathology, Peking University Health Science Center, Beijing, China
  1. Correspondence to Liu Fangfang, Department of Pathology, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing 100044, China; liufangfang{at}pkuph.edu.cn

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A 60-year-old woman presented with a painless lump in the left breast. A solitary movable mass in the left upper–outer quadrant of the breast was palpated on physical examination. It had a hard texture and a poorly defined boundary. Fine-needle aspiration revealed ovoid and spindle-shaped tumour cells with mildly pleomorphic nuclei that were approximately two-to-three times larger than a small lymphocyte (figure 1).

Figure 1

Fine-needle aspiration reveals uniform oval or spindle-shaped cells with a high nuclear-to-cytoplasmic ratio and indistinct borders. Endothelial-lined capillary vessels lie within fragments of tissue (H&E ×200).

The surgical specimen was a non-encapsulated solid mass that measured 4×4×3 cm. Cut sections were haemorrhagic and showed a well-defined tumour border (figure 2). Microscopic examination revealed a solid highly cellular tumour. The tumour cells had ill-defined membrane borders. Some tumour cells were epithelial like, and in many areas they were arranged …

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