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This section features synopses of pertinent practical publications that appear in Pathology journals in the respective sub-specialties. The summaries are mere guidelines and personal opinions of the two authors. The articles selected are diverse but occasionally reflect the authors' bias and are from the more widely read pathology journals. It is not intended to be an assiduous search of every publication in every Pathology journal, but more of a general indication of some of the monthly highlights through the eyes of the authors.
Hopefully, these snippets will provide the reader with enough to glean some facts and tips, as well as encourage them to read the entire article if necessary.
Journal of Clinical Pathology
Miralles-Guri C, Bruni L, Cubilla AL, et al. Human papillomavirus prevalence and type distribution in penile carcinoma. J Clin Pathol 2009;62:870–8.
An excellent review of HPV in penile cancers from 31 published studies. An overall prevalence of 47% (HPV 16—60%; HPV 18—13%; HPV 6/11—8%) confirming predominantly basaloid/warty squamous cell carcinomas (simulating the vulva) are most frequently associated with HPV. However, in contrast, about 50% of keratinising/non-keratinising carcinomas were also HPV-positive.
Balint I, Szponar A, Jauch A, et al. Trisomy 7 and 17 mark papillary renal cell tumours irrespectively of variation of the phenotype. J Clin Pathol 2009;62:892–5.
Trisomy 7/17 is specific for papillary renal cell carcinoma irrespective of cell size/nuclear grade (type 1 papillary renal cell carcinoma is small/basaloid vs type 2 large/eosinophilic).
Shingde MV, Buckland M, Busam KJ, et al. Primary cutaneous Ewing sarcoma/primitive neuroectodermal tumour: a clinicopathological analysis of seven cases highlighting diagnostic pitfalls and the role of FISH testing in diagnosis. J Clin Pathol 2009;62:915–19.
A reminder that the EWS/PNET family of tumours may present as primary cutaneous tumours. Morphology, immunohistochemistry and molecular changes mirror their soft tissue/bone …