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Current practice patterns among pathologists in the assessment of venous invasion in colorectal cancer
  1. David E Messenger1,2,
  2. David K Driman3,4,
  3. Robin S McLeod1,2,5,6,
  4. Robert H Riddell7,8,
  5. Richard Kirsch7,8
  1. 1Zane Cohen Clinical Research Centre, Mount Sinai Hospital, Toronto, Ontario, Canada
  2. 2Division of General Surgery, Mount Sinai Hospital, Toronto, Ontario, Canada
  3. 3Department of Pathology, London Health Sciences Centre, London, Ontario, Canada
  4. 4University of Western Ontario, London, Ontario, Canada
  5. 5Department of Surgery, University of Toronto, Toronto, Ontario, Canada
  6. 6Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada
  7. 7Department of Pathology, University of Toronto, Toronto, Ontario, Canada
  8. 8Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
  1. Correspondence to Dr Richard Kirsch, Assistant Professor, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G 1X5; rkirsch{at}mtsinai.on.ca

Abstract

Aims Venous invasion (VI) is a known independent prognostic indicator of recurrence and survival in colorectal cancer. The guidelines of the Royal College of Pathologists (RCPath) state that, in a series of resections, extramural VI should be detected in at least 25% of specimens. However, there is widespread variability in the reported incidence, and this may affect patient access to adjuvant therapy. This study aims to clarify the current practice patterns of pathologists regarding the assessment of VI and to identify factors associated with an increased self-reported VI detection rate.

Methods A population-based survey was mailed to 361 pathologists in the province of Ontario, Canada.

Results The overall response rate was 64.9%. Most pathologists were practicing in community-based centres (66.2%) and approximately half had been in practice for over 15 years (53.5%). A subspecialist interest in gastrointestinal (GI) pathology was declared by 27.3% of pathologists. The majority of pathologists (70.2%) reported that they detected VI in less than 10% of resection specimens, with only 9.1% reporting VI detection rates above 20%. Standardised reporting criteria were applied by 62.1%. Special stains were employed by 57.6% if VI was suspected on H&E-stained sections. Practice in a university-affiliated centre, a subspecialist interest in GI pathology and the acceptance of the ‘orphan arteriole’ sign were all independently associated with a self-reported VI detection rate above 10% on multivariate analysis.

Conclusions Self-reported VI detection rates are low among most pathologists. Even among specialist GI pathologists practicing in university-affiliated centres, few reported a detection rate close to that recommended by the RCPath. Strategies to increase the detection of VI may be required.

  • Blood vessels
  • colorectal cancer
  • healthcare surveys
  • pathology, surgical
  • specimen handling

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Footnotes

  • Funding David Messenger was supported by The Joseph and Wolf Lebovic Research Fellowship.

  • Competing interests None.

  • Ethics approval Ethical approval for the study was obtained from the Research Ethics Board of Mount Sinai Hospital, Toronto, Canada.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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