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Oncocytic changes define reactive, inflammatory or hyperplastic cellular modifications with cytoplasmic eosinophilia owing to accumulation of mitochondria. The term ‘oncocytic tumour’ is reserved to cases with oncocytes accounting for the entire neoplastic population. Benign and malignant oncocytic tumours are known as oncocytomas and oncocytic carcinomas, respectively. They occur more frequently in kidney and thyroid gland but have also been observed in other organs. In particular, in the prostate they are exceedingly rare, with only three cases described.1–3
We recently observed a 72-year-old man with a 5-year history of dysuria and prostate enlargement. He did not receive either hormonal therapy or chemotherapy before surgery. Histology after prostatectomy documented adenocarcinoma with oncocytic features, which constituted the entirety of the neoplasm; tumour cells were polygonal and medium-sized with …
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