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An imbalance of COX level is not related to placental abruption
  1. Laura Avagliano1,2,
  2. Monica Falleni1,3,
  3. Anna Maria Marconi2,
  4. Camilla Bulfoni2,
  5. Arianna Prada2,
  6. Antonino F Barbera4,
  7. Patrizia Doi1,
  8. Gaetano P Bulfamante1,3
  1. 1Unit of Human Pathology, Department of Medicine, Surgery and Dentistry, San Paolo Hospital Medical School, University of Milano, Italy
  2. 2Unit of Obstetrics and Gynecology, Department of Medicine, Surgery and Dentistry, San Paolo Hospital Medical School, University of Milano, Italy
  3. 3Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena, University of Milano, Italy
  4. 4Department of Obstetrics and Gynecology, Denver Health Medical Center, Denver, Colorado, USA
  1. Correspondence to Anna Maria Marconi, Unit of Obstetrics and Gynecology, Department of Medicine, Surgery and Dentistry, San Paolo, University of Milano, Via A. di Rudinì 8, Milano 20142, Italy; annamaria.marconi{at}unimi.it

Abstract

Aims Muscularised basal plate arteries (MA) or chorioamnionitis (CA) are often present in placental abruption. The aim of this study was to evaluate the placental expression of COX 1 and COX 2 in cases of placental abruption with MA or CA hypothesising that an imbalance in COX placental expression might be implicated in its pathogenesis.

Methods COX 1 and COX 2 placental immunostaining was analysed in 16 placentas with abruption (nine with MA, seven with CA), in 26 normal placentas and in 10 gestational age-matched MA or CA cases without abruption.

Results COX 1 and COX 2 protein expression was observed in all cases, both in placental abruption and in normal placentas. No differences in distribution of immunoreactivity were observed either between cases and controls or between MA and CA. The mean COX 1 ratio between COX-positive cells and all stromal cells was significantly lower in placental abruption with MA (0.14±0.05) when compared with cases with CA (0.35±0.06) and normal placenta (0.23±0.02; p<0.001). The mean COX 2 ratio was lower in placental abruption with MA than in normal placenta (0.09±0.06 vs 0.18±0.05: p<0.001). In contrast, no difference in COX 1 and COX 2 ratio was observed between MA cases with or without abruption and between CA cases with or without abruption.

Conclusions It is hypothesised that an imbalance of normal COX level may be present in cases with MA and CA but it is not related to placental abruption.

  • COX 1
  • COX 2
  • placenta
  • abruption
  • spiral artery
  • chorioamnionitis
  • inflammation

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Footnotes

  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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