Article Text

PDF
Centromere protein F and survivin are associated with high risk and a poor prognosis in colorectal gastrointestinal stromal tumours
  1. Wen-Bin Chen1,
  2. Xiao-Bin Cheng1,
  3. Wei Ding2,
  4. Yang-Jing Wang1,
  5. Dong Chen1,
  6. Jin-Hai Wang1,
  7. Ru-Shan Fei1
  1. 1Department of Colorectal Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China
  2. 2Department of Pathology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China
  1. Correspondence to Wen-Bin Chen, Department of Colorectal Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, #79 Qingchun Road, Hangzhou 310003, Zhejiang Province, PR China; cwbin{at}hotmail.com

Abstract

Aims Colorectal gastrointestinal stromal tumours (GISTs) are considered to be tumours with a relatively poor prognosis. Few reports have been performed to investigate the mechanisms behind their malignant behaviour and to identify new therapeutic strategies for their treatment. The authors conducted this study to explore potential targets for the treatment of colorectal GISTs (CRGISTs).

Methods In the current study, the authors focused on centromere protein F and survivin, two markers that are known to affect the malignant behaviour of other tumours. Expression of centromere protein F and survivin was detected through the immunohistochemical staining of paraffin-embedded tumour tissues and then scored. The relationship between the expression of the two markers and their clinical parameters was analysed. Associated Survival analysis was available based on follow-up information.

Results The authors demonstrated for the first time that centromere protein F and survivin expression were significantly associated with high risk and a poor prognosis (p<0.05) in CRGISTs. The authors also found that centromere protein F expression was more prevalent in males (p=0.002).

Conclusions The results suggest that centromere protein F and survivin are malignant behaviour markers for CRGISTs. The expression of centromere protein F or survivin points to a poor clinical outcome. Interfering with centromere protein F and/or survivin expression might be a potentially therapeutic strategy for treating malignant CRGISTs.

  • Centromere protein F
  • survivin
  • immunohistochemistry
  • gastrointestinal stromal tumours
  • colorectal cancer
  • cancer research
  • histopathology

Statistics from Altmetric.com

Footnotes

  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.