Article Text

PDF
Correspondence
Mean corpuscular haemoglobin, referenced and resurrected
  1. Oscar M P Jolobe
  1. Correspondence to Oscar M P Jolobe, Manchester Medical Society, C/o John Rylands University Library, 1 Philip Godlee Lodge, 842 Wilmslow Road, Manchester M20 2DS, UK; oscarjolobe{at}yahoo.co.uk

Statistics from Altmetric.com

As recently as 2006, to the exclusion of any mention of mean corpuscular haemoglobin (MCH), mean corpuscular volume (MCV) was the sole parameter selected for triggering evaluation of iron status in patients with microcytic anaemia.1 This strategy was, arguably, attributable to the advice emanating from the WHO guideline Assessing the Iron Status of Populations, which recommended MCV as an indicator of iron deficiency on the basis of the fact that ‘MCV indicates whether RBCs are smaller than usual (microcytic) which is a common sign of iron deficiency anaemia…’.2 Accordingly, the observation that ‘the MCH (mean corpuscular haemoglobin) rather than mean corpuscular volume (MCV) has become the most important red cell marker for detecting ID (iron deficiency) in circulating red blood cells’3 deserves to be more fully referenced than was the case in the excellent review of disorders of iron metabolism.3 Nevertheless, it should also be acknowledged that, in many instances, iron deficiency anaemia is both microcytic and hypochromic,4 notwithstanding the fact that hypochromia may antedate the onset of microcytosis.5–8 It was in the retrospective evaluation of 69 subjects with serum ferritin <20 ng/ml that low MCH values (<27 pg) were first documented as being superior to low MCV values (<77 fl) in predicting serum ferritin …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles