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Two cases of opportunistic parasite infections in patients receiving alemtuzumab
  1. Guillaume Desoubeaux1,
  2. Charline Caumont1,
  3. Christophe Passot2,
  4. Caroline Dartigeas3,
  5. Éric Bailly1,
  6. Jacques Chandenier1,
  7. Thanh Haï Duong1
  1. 1Unit of Parasitology - Mycology - Tropical Medicine, CHRU Bretonneau, Tours, France
  2. 2Immunology Laboratory, CHRU Bretonneau, Tours, France
  3. 3Service of Haematology and Cellular Therapy, CHRU Bretonneau, Tours, France
  1. Correspondence to Dr Guillaume Desoubeaux, Unit of Parasitology - Mycology - Tropical Medicine, University Hospital Bretonneau, 2 Blvd Tonnellé, Bâtiment B2A, 37044 Tours Cedex 09, France; guillaume.desoubeaux{at}univ-tours.fr

Abstract

Two cases are reported of rare digestive opportunistic parasites in patients being treated with alemtuzumab for lymphoid haematological malignancies. In both patients, classical biological examinations were insufficient to reach the diagnosis. Only specific parasitological techniques enabled diagnoses of cryptosporidiosis and microsporidiosis, respectively. In both cases, cellular immune reconstitution was sufficient to eradicate these opportunistic infections. In this context, parasitological diagnosis is often underestimated by medical practitioners, so immunologists and oncohaematologists need to be aware of this kind of opportunistic pathogen.

  • Alemtuzumab
  • lymphoid haematological malignancies
  • digestive opportunistic parasitoses
  • cryptosporidiosis
  • microsporidiosis
  • parasites
  • cryptosporidium
  • microsporidium
  • monoclonal antibody

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Footnotes

  • Competing interests None.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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