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Original article
Diagnostic and prognostic relevance of Cullin1 expression in invasive ductal carcinoma of the breast
  1. Kyueng-Whan Min1,
  2. Dong-Hoon Kim2,
  3. Sung-Im Do2,
  4. Jin Hee Sohn2,
  5. Seoung Wan Chae2,
  6. Jung-Soo Pyo2,
  7. Chan Heun Park3,
  8. Young-Ha Oh1,
  9. Ki-Seok Jang1,
  10. Hack-Lyoung Kim4,
  11. Min Kim5
  1. 1Department of Pathology, College of Medicine, Hanyang University, Seoul, South Korea
  2. 2Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea
  3. 3Department of Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea
  4. 4Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea
  5. 5Department of Ophthalmology, Severance Eye and ENT Hospital, Yonsei University College of Medicine, Seoul, South Korea
  1. Correspondence to Professor Dong-Hoon Kim, Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 78 Saemunan-gil, Jongno-Gu, Seoul 110-746, South Korea; idavid.kim{at}samsung.com

Abstract

Background Cullin1 (Cul1) is a matrix degrading enzyme known to be involved in the remodelling of extracellular matrix proteins. This enzyme has recently been reported to play a key role in tumour progression and its presence is associated with poor clinical outcome for several different types of tumours.

Methods 159 patients diagnosed with invasive ductal carcinoma between 2000 and 2005 were studied. Cul1 expression was analysed by immunohistochemical staining on a tissue microarray. The relationship between Cul1 expression and clinicopathological parameters was evaluated.

Results Tumour expression of Cul1 was correlated with prognostic factors such as high histological grade and p53 expression, and was also linked to negative ER and positive HER2 as therapeutic markers (all p<0.05). There was a significant association between poor overall survival and high Cul1 expression in both univariate and multivariate analyses (all p<0.05).

Conclusions Cul1 expression was significantly associated with high-grade tumours and poor prognosis, suggesting that it may play a role in breast tumour progression. Cul1 expression may therefore be crucial for the prediction of disease outcome in breast cancer patients.

  • Invasive ductal carcinoma
  • Cdk-associated Cullin1
  • human
  • prognosis
  • breast

https://doi.org/10.1136/jclinpath-2012-200847

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    Footnotes

    • Additional tables are published online only. To view these files please visit the journal online (http://dx.doi.org/10.1136/jclinpath-2012-200847).

    • Competing interests None.

    • Ethics approval The study was performed according to the Declaration of Helsinki and approved by the Ethics Committee of the Kangbuk Samsung Hospital (KBSMC11105).

    • Provenance and peer review Not commissioned; externally peer reviewed.