P16INK4A overexpression predicts lymph node metastasis in cervical carcinomas
- 1Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan
- 2Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Fu Jen Catholic University, Hsinchuang, Taipei Hsien, Taiwan
- 3Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
- 4Department of Pathology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan
- 5Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
- 6Department of Biomedical Engineering, Yuanpei University, Hsinchu, Taiwan
- Correspondence to Professor Chin-Cheng Lee, Department of Pathology, Shin Kong Wu Ho-Su Memorial Hospital, No. 95, Wen Chang Road, Shih Lin District, Taipei City 111, Taiwan;
Contributors All authors have directly participated in the planning, execution and analysis of the study and have approved the final version submitted.
- Accepted 30 August 2011
- Published Online First 19 October 2011
Background The p16INK4A protein (p16) is a cyclin-dependent kinase inhibitor that arrests the cell cycle in the G1 phase.
Aim To explore the potential of p16 as a predictive marker for lymph node (LN) metastasis and prognosis in cervical carcinomas.
Methods 145 patients diagnosed with FIGO stage I to IV cervical carcinoma were studied; 95 underwent LN dissection. The expression of p16 protein was studied by immunohistochemistry using tissue microarrays.
Results Overexpression of p16 was seen in 108 of 145 (74.5%) invasive carcinomas. There was a significant correlation between p16 expression and LN metastasis (p=0.007). Patients with p16 overexpression had poorer survival than patients with p16 underexpression (59.3% vs 83.8% 5-year survival rate, log-rank p=0.015). In univariate analysis, p16 expression was a significant predictor of survival (RR 2.76, p=0.02).
Conclusions Results suggest that p16 expression is an important predictive factor of LN metastasis in cervical cancer patients. Moreover, p16 overexpression is associated with a poor prognosis. Therefore, immunohistochemical evaluation of p16 expression is of potential value for treatment planning in cervical carcinomas.
- lymph node metastasis
- cervical carcinoma
- tumour markers
Funding This study was supported by research grants (SKH-8302-98-DR-23, SKH-8302-99-DR-29) from the Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Competing interests None.
Patient consent Obtained.
Ethics approval Ethics approval was provided by the Institutional Review Board of Shin Kong Wu Ho-Su Memorial Hospital.
Provenance and peer review Not commissioned; externally peer reviewed.