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High antiphospholipid antibody levels are associated with statin use and may reflect chronic endothelial damage in non-autoimmune thrombosis: cross-sectional study
  1. Anna Broder1,
  2. Jonathan N Tobin2,3,
  3. Chaim Putterman1
  1. 1Division of Rheumatology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York, USA
  2. 2Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA
  3. 3Clinical Directors Network (CDN), New York, New York, USA
  1. Correspondence to Dr Anna Broder, Division of Rheumatology, Albert Einstein College of Medicine/Montefiore Medical Center, Forchheimer Building, Room 701N, 1300 Morris Park Avenue, Bronx, NY 10461, USA; abroder{at}montefiore.org

Abstract

Objective Persistently elevated antiphospholipid antibodies and positive lupus anticoagulant (LAC) are associated with an increased risk of thrombosis. The objective of this study was to explore whether antiphospholipid antibody and/or LAC positivity were associated with the traditional risk factors for thrombosis or with medication use in patients without autoimmune diseases hospitalised with arterial or venous thrombosis.

Design Cross-sectional study.

Setting Montefiore Medical Center, a large urban tertiary care centre.

Patients 270 patients (93 with deep vein thrombosis (DVT) or pulmonary embolism (PE), and 177 with non-haemorrhagic stroke (cerebrovascular accident (CVA)) admitted between January 2006 and December 2010 with a discharge diagnosis of either DVT, PE or CVA, who had LAC and antiphospholipid antibodies measured within 6 months from their index admission. Patients with lupus or antiphospholipid syndrome were excluded.

Main Outcome Measures The main dependent variable was antiphospholipid antibodies of 40 units or greater (antiphospholipid antibody positivity) and/or LAC positivity. Independent variables were traditional thrombosis risk factors, statin use, aspirin use and warfarin use.

Results 31 (11%) patients were LAC positive and/or antiphospholipid antibody positive. None of the traditional risk factors at the time of DVT/PE/CVA was associated with antiphospholipid antibody positivity. Current statin use was associated with an OR of 3.2 (95% CI 1.3 to 7.9, p=0.01) of antiphospholipid antibody positivity, adjusted for age, ethnicity and gender. Aspirin or warfarin use was not associated with antiphospholipid antibody levels.

Conclusion If statin therapy reflects the history of previous hyperlipidaemia, high levels of antiphospholipid antibodies may be a marker for earlier endothelial damage caused by hyperlipidaemia.

  • Antiphospholipid
  • antiphospholipid antibodies
  • endothelial damage
  • endothelium
  • lipids
  • statins
  • stroke
  • thrombosis

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Footnotes

  • Funding This project was funded in part by an empire clinical research investigator program career development award to AB. The funding source played no role in the study's design, conduct, or reporting.

  • Competing interests None declared.

  • Ethics approval This project was approved by the Institutional Review Board at Albert Einstein College of Medicine/Montefiore Medical Center.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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