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Mucinous tumours of the ovary
  1. Jay D Naik1,2,
  2. Jenny Seligmann1,
  3. Timothy J Perren1
  1. 1Department of Medical Oncology, St James's Institute of Oncology, Beckett Street, Leeds, UK
  2. 2Mid Yorks NHS Trust, Wakefield, UK
  1. Correspondence to Jay Naik, Department of Medical Oncology, St James's Institute of Oncology, Leeds LS9 7TF, UK; jay.naik{at}leedsth.nhs.uk

Abstract

Mucinous epithelial ovarian cancers (mEOC) are a relatively rare subset of ovarian cancers. Despite a relatively favourable outcome in early disease, the more frequent advanced presentation is associated with poorer response to platinum/taxane chemotherapies, and poorer survival, compared to serous ovarian cancers. We consider some of the fundamental clinico-pathological and molecular features, and existing clinical trial data regarding mEOC. Underlying molecular differences, between mEOC and serous cancers may contribute to the observed clinical differences, including an increased prevalence of K-RAS mutations in mEOC, more in keeping with gastrointestinal tumours. This observation contributes to the rationale for a trial (“mEOC”) investigating the use of “ovarian” versus “gastrointestinal” style chemotherapy. Looking to potential future approaches, we speculate upon the potential impact of emerging technologies on the future investigation and management of mEOC.

  • Mucinous ovarian cancer
  • serous ovarian cancer
  • clinical trials
  • targeted therapies
  • breast cancer
  • ovarian tumour
  • uterus

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Footnotes

  • JDN and JS contributed equally to writing of this article.

  • Competing interests None.

  • Provenance and peer review Commissioned; externally peer reviewed.

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