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- Head and neck cancer
- cervical cancer
- colorectal cancer
- gall bladder
Currently more than 200 types of human papillomaviruses (HPV) have been classified, where the low-risk ones are those that are not capable of developing into cancer while the high-risk ones are.1 Cervical cancer and its preceding lesions have been strongly associated with HPV, mainly through the high-risk 16/18 strains. Due to morphological similarities between the cervical mucosa and the upper aerodigestive tract, it is suggested that HPV be proposed as an aetiological factor in the developing of oral cancer.2
In 1978, WHO defined leukoplakia as a white plaque of oral mucosa, not removable by scraping, which cannot be characterised clinically or pathologically as any other disorder.3 Recent publications have grouped leukoplakia with lesions that precede oral cancer or those that are potentially malignant.4 HPV's role in the aetiology and malignisation of precancerous oral lesions has been studied; however, the results achieved are still not conclusive. The purpose of this study was to identify the prevalence of HPV 16/18 in patients with verrucous leukoplakia of the oral mucosa, along with a profile of their social demographics.
The UNIARARAS community, located in Araras, São Paulo, Brazil, was divided in two groups: …