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- ectopic thymoma
- connective tissue diseases
Cervical ectopic thymoma is extremely rare, and, till date, <30 cases have been reported in the literature.1 Although typical cases of thymic neoplasms show distinctive morphology, they may pose diagnostic challenges when the specimen consists of only small tissue as often encountered in needle biopsy. Cervical ectopic thymoma is often misdiagnosed as thyroid or lymph node masses; specifically, predominantly lymphocytic thymoma can be misdiagnosed as Hashimoto's thyroiditis or malignant lymphoma and predominantly epithelial thymoma as carcinoma, particularly of thyroid origin.2 Therefore, the availability of thymus-specific immunohistochemical markers that can verify thymic epithelial origin would be of great help in getting a proper diagnosis.
β5t is a recently discovered proteasomal β subunit expressed exclusively in thymic cortical epithelial cells in both humans and mice.3 ,4 It is a component of specialized 20S proteasomes known …
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