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Breast pathology today: morphology and molecules
  1. Emad A Rakha1,
  2. Sandra A O'Toole2,
  3. Ian O Ellis1,
  4. Puay Hoon Tan3
  1. 1Department of Pathology, University of Nottingham, Nottingham, UK
  2. 2Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
  3. 3Department of Pathology, Singapore General Hospital, Singapore
  1. Correspondence to Dr Puay Hoon Tan, Department of Pathology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore; tan.puay.hoon{at}sgh.com.sg

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This theme issue on breast pathology is a blend of articles of relevance for today's diagnostic practice that focuses on morphological recognition and classification of breast tumours, integration with molecular features and contribution to management decisions. The molecular reviews open the window into a future where scientific investigations into pathogenesis and biology of breast disease can be potentially translated into effective therapeutics for women with breast cancer.

Classification of breast tumours remains a mainstay of pathological assessment. In light of the recent publication of the 4th edition of WHO Classification of Tumours of the Breast in 2012,1 an update is provided of specific entities of myoepithelial, epithelial–myoepithelial, mesenchymal and fibroepithelial lesions.2 Key changes concerning these conditions emanating from the prior edition, and the rationale behind some of the revisions are summarised. Apart from emergent data …

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