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Sir, Hyperplastic polyps and tubulovillous adenomas, as well as collagenous/lymphocytic colitis, are not infrequently encountered diagnoses in colonic biopsies. Although this finding is well known, and not in the least bit surprising, to gastrointestinal pathologists (reviewer personal communication), potential differing aspects of this have neither been explored nor documented for non-gastrointestinal pathologists. Herein, the features of 10 such cases are reported with an emphasis on differences between type of polyp and inflammatory/collagenous changes in microscopic colitis.
The 10 cases are summarised in table 1. All biopsies were stained with H&E and with Masson trichrome, CD3 and CD8. Seven of the 10 cases showed features typical of collagenous colitis in random colonic biopsies. Three …