Figure 1

Neurogenic damage and mitochondrial dysfunction in the myopathy during the treatment of lamivudine/telbivudine. (A) Variation of the muscle fibre size, angulated fibres (arrow), hypertrophy fibres (arrowhead) can be observed in patient 5 (haematoxylin and eosin; original magnification, ×400). (B) Cytochrome c oxidase-deficient fibres (arrow) in patient 6 (cytochrome c oxidase, original magnification, ×400). (C) Ragged blue fibres (arrow) in patient 4 (succinate dehydrogenase; original magnification, ×400); (D) ragged red fibres (arrow) in patient 6 (modified Gomori trichrome; original magnification, ×400).