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An intravascular large B-cell lymphoma with a t(3;14)(q27;q32) translocation
  1. Jing Cui1,
  2. Qun Liu1,
  3. Yuxia Cheng1,
  4. Shaoyu Chen2,
  5. Qing Sun1
  1. 1Department of Pathology, Qianfoshan Hospital Affiliated with Shandong University, Jinan, Shandong Province, China
  2. 2Guang Zhou LBP Medicine Science and Technology Co., LTD., Guangzhou, Guangdong Province, China
  1. Correspondence to Dr Qing Sun, Department of Pathology, Qianfoshan Hospital Affiliated with Shandong University, Jinan, Shandong Province 250014, China; qingsw99{at}163.com

Abstract

A 61-year-old man with no symptom was found with bilateral adrenal nodules on CT scan during a routine physical check-up. The left nodule was removed by adrenalectomy, and the patient was diagnosed with intravascular large B-cell lymphoma (IVLBCL) on pathological and immunohistochemical examinations. Using a set of dual-colour, break-apart probes and fluorescence in situ hybridisation, it was revealed that the lymphoma cells have tetraploid karyotype, with a breakpoint in BCL6 gene, which was further confirmed as a t(3;14)(q27;q32) translocation. To the best of our knowledge, this is the first report of IVLBCL with such a translocation.

  • HAEMATOPATHOLOGY
  • LYMPHOMA
  • ADRENAL GLAND

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