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EGFR expression in pancreatic adenocarcinoma. Relationship to tumour morphology and cell adhesion proteins
  1. Adriana Handra-Luca1,2,
  2. Pascal Hammel3,4,
  3. Alain Sauvanet4,5,
  4. Claude Lesty6,
  5. Philippe Ruszniewski3,4,7,
  6. Anne Couvelard4,7,8
  1. 1Département d'Anatomie pathologique, APHP Hôpital Avicenne, Bobigny, France
  2. 2Université Paris Nord Sorbonne Cite, Bobigny, France
  3. 3Service de Gastroentérologie-Pancréatologie, APHP Hôpital Beaujon, Clichy, France
  4. 4Université Paris Diderot Sorbonne Cite, Paris, France
  5. 5Service de Chirurgie Digestive, APHP Hôpital Beaujon, Clichy, France
  6. 6Laboratoire de Hématologie Biologique, APHP Hôpital Pitie-Salpetriere, Paris, France
  7. 7INSERM U773 Centre de Recherche Biomédicales Bichat Beaujon CRB3, Paris, France
  8. 8Département d'Anatomie pathologique, APHP Hôpital Bichat Claude Bernard, Paris, France
  1. Correspondence to Dr Adriana Handra-Luca, Service d'Anatomie pathologique, APHP GHU Avicenne, Université Paris Nord Sorbonne Cité, 125 rue de Stalingrad, Bobigny 93000, France; adriana.handra-luca{at}avc.aphp.fr

Abstract

Aims We aimed to study epidermal growth factor receptor (EGFR) expression in surgically resected pancreatic ductal adenocarcinomas (PDACs) by immunohistochemistry and their relationship to clinicopathological features, cell proliferation and cell adhesion protein expression.

Methods A total of 99 PDACs were analysed on tissue microarrays for EGFR, E-cadherin and β-catenin expression patterns in tumour cells. The percentage of cells expressing the three proteins (membrane, cytoplasm or nuclear pattern) and of Ki67-positive tumour cells was assessed. Tumour protein expression was studied with regard to clinicomorphological features, Ki67 index and for postsurgical survival.

Results Membrane tumour EGFR correlated with histological poor differentiation (dedifferentiation), increased number of mitoses and severe tumour cell atypia (pleiomorphism) as well as with aberrant adhesion protein expression such as nuclear β-catenin and cytoplasmic E-cadherin. Cytoplasmic tumour E-cadherin correlated with an increased Ki67-positive tumour cell component, whereas nuclear E-cadherin correlated with a shorter postsurgical overall survival, as well as with tumour necrosis and an abundant clear cell component.

Conclusions In conclusion, the results of our study suggest a complex role for EGFR in PDAC carcinogenesis, tumour expression of this protein being associated with tumour dedifferentiation, mitotic activity or pleiomorphism, as well as with aberrant tumour cell adhesion protein expression.

  • Carcinoma
  • Immunohistochemistry
  • Pancreas

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