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Serum pepsinogen reference intervals in apparently healthy Chinese population with latex enhanced turbidimetric immunoassay
  1. Meng Huang,
  2. Ai-Guo Tang,
  3. Sa Mu,
  4. Jing-Jing Yang,
  5. Zhong-Yuan Xiang,
  6. Bo Liu,
  7. Jia-Jin Yang
  1. Department of Clinical Laboratory, Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China
  1. Corresponding to Jia-Jin Yang, Department of Clinical Laboratory, Second Xiangya Hospital, Central South University, 139 Renmin Zhong Road, Changsha, Hunan 410011, PR China; Yangjiajin1988{at}163.com

Abstract

Aim Serum pepsinogen (sPG) has been used to help in diagnosing atrophic corpus gastritis and in screening for gastric cancer non-invasively. There are as yet no reports on sPG reference intervals (RIs) with latex enhanced turbidimetric immunoassay (LIA). In this study, we established the RIs for sPG in a healthy Chinese population using LIA.

Methods Serum PGI and PGII levels in a healthy population (aged 17–80 years) were measured simultaneously using LIA. RIs were determined following Clinical Laboratory and Standards Institute C28-A3 guidelines using a non-parametric method.

Results 95% RIs in men (ng/mL) were: ≤40 years old, 25.53–100.76 for PGI and ≤24.42 for PGII; 41–50 years old, 26.62–124.74 for PGI and ≤26.81 for PGII; and 51–80 years old, 30.40–153.25 for PGI and ≤32.62 for PGII. Corresponding RIs for women (ng/mL) were: ≤40 years old, 21.20–87.44 for PGI and ≤25.53 for PGII; and 41–80 years, 26.40–127.46 for PGI and ≤30.18 for PGII. 95% RI for PGI/PGII in both men and women at any age was ≥2.51.

Conclusions We established the RIs for sPG using LIA in a healthy Chinese population, which can provide a reference for clinical and laboratory studies.

  • GASTRIC CANCER
  • diagnostic screening
  • GASTRITIS
  • LABORATORY TESTS

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