Footnotes

• Contributors HL collected the experimental data. RKF, SMG and JW provided clinical input. AR, PW, PGI and M-QD reviewed the histology and immunohistochemistry. M-QD analysed the data and drafted the manuscript. All authors reviewed and commented on the manuscript and approved its submission.

• Funding The research in M-QD lab was supported by grants from Leukaemia & Lymphoma Research, UK, the Kay Kendal Leukaemia Fund, UK.

• Competing interests None.

• Patient consent Obtained.

• Ethics approval Oxfordshire REC A.

• Provenance and peer review Not commissioned; externally peer reviewed.