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The chemokine receptor CXCR7 influences prognosis in human glioma in an IDH1-dependent manner
  1. Peter Birner1,
  2. Andrey Tchorbanov2,
  3. Sevdalin Natchev3,
  4. Jochen Tuettenberg4,
  5. Marin Guentchev4
  1. 1Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria
  2. 2Department of Immunology, Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria
  3. 3Department of Neuropathology, St. Ivan Rilski Hospital, Sofia, Bulgaria
  4. 4Department of Neurosurgery, Klinikum Idar-Oberstein, Idar-Oberstein, Germany
  1. Correspondence to Dr Marin Guentchev, Department of Neurosurgery, Klinikum Idar-Oberstein, Dr. Ottmar-Kohler Str. 2, Idar-Oberstein 55743, Germany; guentchev{at}gmail.com

Abstract

Aims The chemokine receptor CXCR7 is found on glioma cells and glioma-associated vessels and dependent upon its localisation on tumour or endothelial cells the CXCR7 receptor can mediate glioma cell invasion and tumour angiogenesis. Its expression predicts survival in several types of cancers.

Methods We immunohistochemically studied the expression of CXCR7 and its ligand SDF1α in a cohort of 354 human patients with glioma. In an in vivo glioma model, we studied the effect of selective CXCR7 inhibition on mean vascular density.

Results Here we show that expression of either mutant isocitrate dehydrogenase (IDH) 1 or podoplanin (PDPN), two proteins present in basically non-overlapping glioma populations, predicts the prognostic significance of CXCR7. Specifically, expression of CXCR7 on endothelial cells in IDH1 mutant cases predicted poor outcome. Surprisingly, in PDPN expressing gliomas, one of the marker genes for the recently identified mesenchymal subgroup, expression of CXCR7 predicts diminished prognosis on tumour cells and better prognosis on endothelial cells.

Conclusions Since CXCR7 is expressed on migrating cells our data suggest that, although ubiquitously present, angiogenesis and invasion are outcome-relevant events in specific glioma subgroups, providing a potentially important tool for targeted therapy assignment.

  • BRAIN TUMOURS
  • NEOPLASMS
  • NEURO-ONCOLOGY
  • NEUROPATHOLOGY

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