Article Text

PDF
Plasma levels of matrix metalloproteinase-2 and -9 in male and female patients with cirrhosis of different aetiologies
  1. Chih-Yang Huang1,2,
  2. Kuo-Chih Tseng3,4,
  3. Ming-Nan Lin4,5,
  4. Jen-Pi Tsai4,6,7,
  5. Cheng-Chuan Su8,9
  1. 1Graduate Institutes of Basic and Chinese Medical Sciences, China Medical University, Taichung, Taiwan
  2. 2Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan
  3. 3Department of Internal Medicine, Buddhist Dalin Tzu Chi Hospital, Chiayi, Taiwan
  4. 4School of Medicine, Tzu Chi University, Hualien, Taiwan
  5. 5Department of Family Medicine, Buddhist Dalin Tzu Chi Hospital, Chiayi, Taiwan
  6. 6Department of Nephrology, Buddhist Dalin Tzu Chi Hospital, Chiayi, Taiwan
  7. 7Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
  8. 8Departments of Clinical Pathology and Anatomic Pathology, Buddhist Dalin Tzu Chi Hospital, Chiayi, Taiwan
  9. 9Departments of Laboratory Medicine and Pathology, School of Medicine, Tzu Chi University, Hualien, Taiwan
  1. Correspondence to Dr Cheng-Chuan Su, Department of Clinical Pathology, Buddhist Dalin Tzu Chi Hospital, 2 Minsheng Road, Dalin Town, Chiayi County 622, Taiwan; sucpo{at}yahoo.com.tw

Abstract

Background Liver fibrosis and cirrhosis may be reversible in some circumstances. Reliable diagnostic tests are necessary for monitoring hepatic fibrogenesis. Matrix metalloproteinase (MMP)-2 and MMP-9 are two of the major MMPs in the circulation and may be most relevant to hepatic fibrosis. The behaviour of MMPs may be significantly different in men and women and may also differ in cases of cirrhosis of various aetiologies.

Aims To evaluate the manifestations of MMP-2 and MMP-9 in liver cirrhosis of different aetiologies in men and women and to compare these patterns with those of healthy controls.

Methods We measured MMP-2 and MMP-9 levels in plasma samples from 112 patients with cirrhosis and 112 age- and gender-matched healthy controls. We then correlated these MMP levels with gender and disease aetiology.

Results Plasma MMP-2 concentrations in patients showed a trend towards increasing values with cirrhosis severity and were markedly increased in patients regardless of gender and aetiology compared with healthy controls (p<0.0001). Plasma mean MMP-9 levels were comparable in patients with cirrhosis and controls, but increased with disease severity. They were significantly lower in patients (130.5 ng/mL), female patients (85.4 ng/mL) and male patients (150.4 ng/mL) with mild cirrhosis than in controls (163.2 ng/mL), female controls (162.5 ng/mL) and male controls (163.3 ng/mL) (p=0.001, 0.041 and 0.009, respectively). MMP-2 and MMP-9 concentrations were not significantly different between genders among controls and among various patient subgroups.

Conclusions Plasma MMP-2 level may be a useful diagnostic marker for monitoring hepatic fibrogenesis in patients with disease of different aetiologies.

  • LIVER DISEASE
  • CHEMICAL PATHOLOGY
  • EXTRACELLULAR MATRIX
  • COLLAGENASE
  • fibrosis

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.