Article Text

This article has a correction. Please see:

PDF
A novel clonal t(1;4)(p36.1;q31) translocation in acute promyelocytic leukaemia
  1. Xueya Zhang,
  2. Jingxin Pan
  1. Department of Hematology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
  1. Correspondence to Dr Xueya Zhang, Department of Hematology, The Second Affiliated Hospital of Fujian Medical University, 34 Zhongshan North Road, Quanzhou 362000, China; jakey3456{at}sina.com.cn

Abstract

The majority of patients with acute promyelocytic leukaemia (APL) carry the hallmark t(15;17)(q22;q21) translocation, involving the promyelocytic leukaemia/retinoic acid receptor-α (PML/RARα) fusion gene, and by sensitivity of blast cells to all-trans retinoic acid (ATRA) and/or arsenic trioxide therapy. The incidence and prognostic significance of additional chromosomal abnormalities in APL are still obscure. We reported a patient with APL with PML/RARα and clonal t(1;4)(p36.1;q31) positive, but t(15;17)(q22;q21) negative. She was initially treated with ATRA and idarubicin and got complete remission. Our report supports the suggestion that there are no differences in the clinical outcome between APL cases with classical t(15;17)(q22;q21) and those with additional chromosomal abnormality t(1;4)(p36.1;q31). To our knowledge, this is the first report of a patient with APL without classical t(15;17)(q22;q21), showing an additional clonal t(1;4)(p36.1;q31) and involving PML/RARα fusion gene. It will help us to understand the role of the clonal t(1;4)(p36.1;q31) translocation in the pathogenesis of APL when relevant genes involved in the clonal translocation have been identified.

  • HAEM-ONCOLOGY
  • LEUKAEMIA
  • CHROMOSOMES

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles

  • Electronic pages
    BMJ Publishing Group Ltd and Association of Clinical Pathologists