Article Text

PDF
Arterial hypoxaemia and its impact on coagulation: significance of altered redox homeostasis
  1. Lewis Fall,
  2. Karl J New,
  3. Kevin A Evans,
  4. Damian M Bailey
  1. Faculty of Computing, Engineering and Science, Neurovascular Research Laboratory, Research Institute of Science and Health, University of South Wales, Glyntaff, UK
  1. Correspondence to Dr Lewis Fall, Faculty of Computing, Engineering and Science, Neurovascular Research Laboratory, University of South Wales, Glyntaff CF37 4AT, UK; lewis.fall{at}southwales.ac.uk

Abstract

Aims Arterial hypoxaemia stimulates free radical formation. Cellular studies suggest this may be implicated in coagulation activation though human evidence is lacking. To examine this, an observational study was designed to explore relationships between systemic oxidative stress and haemostatic responses in healthy participants exposed to inspiratory hypoxia.

Results Activated partial thromboplastin time and international normalised ratio were measured as routine clinical biomarkers of coagulation and ascorbate free radical (A•−) as a direct global biomarker of free radical flux. Six hours of hypoxia activated coagulation, and increased formation of A•−, with inverse correlations observed against oxyhaemoglobin saturation.

Conclusions This is the first study to address the link between free radical formation and coagulation in vivo. This ‘proof-of-concept’ study demonstrated functional associations between hypoxaemia and coagulation that may be subject to redox activation of the intrinsic pathway. Further studies are required to identify precisely which intrinsic factors are subject to redox activation.

  • COAGULATION
  • HAEMOSTASIS
  • CLOTTING

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.