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Hodgkin lymphoma associated T-cells exhibit a transcription factor profile consistent with distinct lymphoid compartments
  1. Cigdem Atayar (c.atayar{at}path.umcg.nl)
  1. Universty Medical Centre Groningen, Netherlands
    1. Anke van den Berg (a.van.den.berg{at}path.umcg.nl)
    1. University Medical Center Groningen, Netherlands
      1. Tjasso Blokzijl (t.blokzijl{at}path.umcg.nl)
      1. University Medical Center Groningen, Netherlands
        1. Marcel Boot (m.boot{at}path.umcg.nl)
        1. University Medical Center Groningen, Netherlands
          1. Randy D Gascoyne (rgascoyn{at}bccancer.bc.ca)
          1. British Columbia Cancer Center, Canada
            1. Lydia Visser (l.visser{at}path.umcg.nl)
            1. University Medical Center Groningen, Netherlands
              1. Sibrand Poppema (s.poppema{at}rvb.umcg.nl)
              1. University Medical Center Groningen, Netherlands

                Abstract

                Aims: Hodgkin lymphoma (HL) is characterized by an ineffective immune response that is predominantly mediated by CD4+ T-cells. We analyzed the expression of the key regulatory T-cell transcription factors (TFs) in the T-cells of HL involved tissues to assess the nature of the TH immune response in HL.

                Methods and results: By immunohistochemistry, GATA3 strongly and T-bet was exclusively expressed in a subset of interfollicular lymphocytes in the reactive lymphoid tissues. In classical HL (cHL), that is generally located in the interfollicular zones, a predominance of T-bet+ T-cells and lesser amounts of GATA3+ and c-Maf+ T-cells was found, concordant with the pattern of the normal interfollicular compartment. In reactive lymphoid tissues, c-Maf was observed mostly in T-lymphocytes within the germinal centers (GCs). Nodular lymphocyte predominance type of Hodgkin lymphoma (NLPHL) and progressively transformed germinal centres cases, showed a majority of c-Maf+ T-cells, consistent with the pattern in normal GCs. NLPHL cases uniformly showed c-Maf+/CD57+ T-cell rosettes around the neoplastic cells, whereas these rosettes were absent in 'Paragranuloma-type' T- cell/histiocyte rich B-cell lymphoma.

                Conclusions: T-cell TF expression profiles of the reactive T-cells in both subtypes of HL are in accordance with the expression profile observed in the distinct lymphoid compartments

                • Hodgkin lymphoma
                • T-cell transcription factors
                • T-helper cells
                • nodular lymphocyte predominance type of Hodgkin lymphoma
                • progressive transformation of germinal centers

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